?? ???? ????? ???? ????? ?? ?????? ??????? ?????? ?????? ??? ???? ????? ?? ??? ???????? ??? ?? ??? ????? ???? ????? ?? ???? ?? ??? ???? ??????? ?? ?????? ????? ???? ?????? ????? ??????.To cut back the risk of respiratory depression, appropriate dosing and titration of OPANA ER are crucial [see DOSAGE AND ADMINISTRATION]. Overestimating the OPANA ER